Merotelic Kinetochore Orientation
Aurora A kinase
contributes to a pole-based error correction pathway.
Ye A.A., Deretic J., Hoel C.M., Hinman A.W.,
Cimini D., WelburnJ.P., and
MarescaT.J. (2015)
Curr. Biol., 25: 1842-1851.
The mitotic origin of
chromosomal instability.
Bakhoum S.F., Silkworth W.T., Nardi I.K., Nicholson J.M., Compton D.A., and
Cimini
D. (2014)
Curr. Biol., 24: R148-149.
Multipolar
spindle pole coalescence is a major source of kinetochore mis-attachment
and chromosome mis-segregation in
cancer cells.
Silkworth W.T., Nardi I., Scholl L.M., and
Cimini D. (2009).
PloS ONE, 4(8): e6564.
Kinetochore
microtubule dynamics and attachment stability are regulated by Hec1.
DeLuca J.G., Gall W.E., Ciferri C.,
Cimini D., Musacchio A., and Salmon
E.D. (2006).
Cell, 127: 969-982.
[
Cited
in Faculty of 1000]
Aurora
kinase promotes turnover of kinetochore microtubules to reduce chromosome
segregation errors
due to merotelic kinetochore
orientation.
Cimini D., Wan X., Hirel C.B., and Salmon E.D. (2006).
Curr. Biol., 16: 1711-1718.
[Highlighted in a Dispatch by Zhang and Walczak in Curr. Biol., 16: r677-r678]
Anaphase
spindle mechanics prevent mis-segregation of merotelically oriented
chromosomes.
Cimini D., Cameron L.A., and Salmon E.D. (2004).
Curr. Biol., 14: 2149-2155.
[Dispatch by Tarun M. Kapoor in Curr. Biol., 14: R1011-R1013; Research Roundup article by
William A. Wells
in J. Cell Biol., 168: 10;
Cited in Faculty of
1000]
Merotelic
kinetochore orientation occurs frequently during early mitosis in mammalian
tissue cells,
and error correction is achieved by
two different mechanisms.
Cimini D., Moree B., Canman J.C., and Salmon E.D. (2003).
J. Cell Sci., 116: 4213-4225.
[
Cited in Faculty of
1000]
Merotelic
kinetochore orientation versus chromosome mono-orientation in the
origin of lagging chromosomes
in
human primary cells.
Cimini D., Fioravanti D., Salmon E.D., Degrassi F. (2002).
J. Cell Sci., 115 (3): 507-515.
Merotelic
kinetochore orientation is a major mechanism of aneuploidy in mitotic
mammalian tissue cells.
Cimini D., Howell B.J., Maddox P., Khodjakov A., Degrassi F., and Salmon
E.D. (2001).
Journal of Cell Biology, 153: 517-527.
[Cover Article: Highlighted in "In Brief" by William A. Wells on the same issue of
the
Journal of Cell Biology]